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the local media sub-system for ownership. If further media objects are speci ed in the set, then the local media sub-system itself creates DMedia instances for these on behalf of the driver. The DPrimaryMediaBase class contains the member iDfcQ, a pointer to a DFC queue. As we have seen earlier in the book, a DFC queue is associated with a kernel thread. If the driver that creates the DPrimaryMediaBase object assigns a DFC queue to this member, then this con gures the media set so that its requests are implemented in the context of the kernel thread associated with that DFC queue. The driver may use a standard kernel queue or create its own. If iDfcQ is left null, then this con gures the media set so that its requests are executed in the context of the client thread. Each local drive request is encapsulated as a TLocDrvRequest a class derived from TThreadMessage, the kernel message class. A request ID is de ned for every request type. TLocDrvRequest contains information pertaining to the request, including the ID and any associated parameters such as the drive position, length and source/destination location.

where this theory has been adopted are data dissemination, broadcast protocols, and routing. We will delve into some of these areas where Epidemic Theory has been used to study and model several processes and functions of sensor networks.

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Therefore, despite the aforementioned limitations, much progress has been made in understanding the molecular aspects of lovirus replication and pathogenesis As a result, these efforts have brought to light a number of potential targets for antiviral therapies and methods to effectively treat infected individuals For example, antivirals currently under investigation include those that may be used prophylactically, as well as those that may be used therapeutically In addition, antivirals that act directly on the virus as well as those that act indirectly by changing the course of disease are also under investigation In this chapter we highlight some of the antiviral strategies currently being pursued for Ebola virus including the development of drugs to target speci c steps of the viral life cycle, agents that may alter disease pathogenesis, and effective immunization strategies to prevent infection during an outbreak..

Requests for an entire set of DMedia objects are all delivered to the primary media object. This takes place in the context of the calling client thread (normally a le server drive thread). The DPrimaryMediaBase class owns a kernel message queue, iMsgQ. If the media is con gured to use a kernel thread, then each request is sent to the queue and the client thread then blocks waiting for the message to complete. Meanwhile, in the context of the kernel thread, the request is retrieved from the queue and dispatched to the appropriate media driver for processing (which normally takes place within driver interrupt service routines and subsequent DFCs). If the media is con gured to use the client thread, then requests are not queued, but instead dispatched straight to the media driver to be processed in the context of the client thread. I discussed the differences between implementing driver requests in the context of the client thread or a kernel thread in 12, Drivers and Extensions.

33 DATA DISSEMINATION IN SENSOR NETWORKS: MODEL AND PROTOCOLS The problem of reliable data dissemination in the context of wireless sensor networks is very critical Reliable data dissemination to all nodes is absolutely necessary for the propagation of queries, code updates, and other sensitive information in a wireless sensor network This is not a trivial task since the number of nodes in a sensor network can be quite huge and the environment is dynamic (ie, nodes can die or move), thus making the topology change constantly Since data dissemination primarily deals with the transfer of messages from one node to all nodes of a network, algorithms based on epidemiological formulations are a perfect t.

West Nile virus (WNV) is mainly an avian virus that is spread by mosquitoes. Since the WNV epidemic in New York City in 1999 the virus is gaining attention worldwide. There are currently no drugs or vaccines available to treat or prevent the disease. Although there are several potential targets for antiviral therapy, like blockade of viral entry, capping, or protein synthesis, the most promising approach appears to be the inhibition of viral enzymes directly involved in virus replication. In WNV, the replication complex consists of two main nonstructural (NS) proteins, NS3 and NS5. NS3 exerts nucleoside triphosphatase (NTPase)/helicase and protease activities, whereas NS5 acts as RNA-dependent RNA polymerase (RdRp). This chapter summarizes our knowledge about the potential targets of anti-WNV therapy, updates the spectrum of inhibitors (blockers) of these targets, and describes the putative mechanisms by which the compounds might act. Some of the compounds presented here exhibited very low cytotoxicity combined with an unambiguous anti-WNV effect when tested in cell culture. Such compounds could show potential utility as a basis for the development of antiviral agents against WNV. 12.2 THE WEST NILE VIRUS

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