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However strong the link between eating disorders and serotonin seems to be, it is unlikely that a speci c dysfunction of one neurotransmitter system can fully explain the pathogenesis of anorexia nervosa and bulimia nervosa. Preclinical studies indicate that other neurochemicals are involved in the initiation, continuation, and termination of a meal. CNS norepinephrine and neuropeptide Y contribute to enhanced food intake, possibly by increasing hunger. Dopamine and endogenous opiates are likely to play a role in food reward. Cholecystokinin, like serotonin, appears to contribute to post-ingestive satiety. Leptin is thought to serve as a metabolic signal for decreased food intake and increased energy metabolism. Finally, ghrelin, a recently discovered gastric peptide, has been demonstrated to increase appetite and food intake in humans. Fasting plasma levels of ghrelin have been found to be elevated in patients diagnosed with anorexia nervosa (Otto et al., 2001). Homovanillic acid (HVA), the major metabolite of dopamine, was decreased in CSF of underweight anorexic subjects (Kaye et al., 1984) and in bulimic patients who had a high binge frequency (Kaye et al., 1990; Jimerson et al., 1992). Kaye et al. (1999) studied women who had recovered from anorexia and bulimia nervosa and compared them to healthy controls. CSF HVA was signi cantly lower in former restricting-type anorexic women compared to bulimia nervosa, bulimic-type anorexic women and control women. CSF MHPG, a norepinephrine metabolite, showed similar values in all groups. Consequently, a traitrelated disturbance of dopamine metabolism may contribute to a vulnerability to develop restricting-type anorexia nervosa.

PRINT " n z z p" PRINT " n z z p n = Negative" PRINT "0.5 + n z z p z = Zero" PRINT " n z z p p = Positive" PRINT " zn pz" PRINT " z n p z" PRINT " z n p z" PRINT "0.0 +zpzpzpzpz+ppppppppp+nnnnnnnnn+znznznznz+" PRINT " 2LLEZ LLEZ 0 ULEZ 2ULEZ" PRINT " (-10) (-5) 0 (5) (10) (Defaults)" PRINT PRINT "Press any key to continue..." WHILE INKEY$ = "": WEND PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT WHILE PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT PRINT "RATE:" "1.0 +nnnnnnnnnn z ppppppppppp" " n z z p" " n z z p" " n z z p" " n z z p n = Negative" "0.5 + n z z = Zero" " z n p z p = Positive" " z n p z" " z z n p z" " z np z" "0.0 +zpzpzpzpz+ppppppppp+nnnnnnnnn+znznznznz+" " 2LLRZ LLRZ 0 ULRZ 2ULRZ" " (-20) (-10) 0 (10) (20) (Defaults)" "Press any key to continue..." INKEY$ = "": WEND "CONTROL" "1.0 nb ns z ps pb" " nb ns z ps pb" " nb ns z ps pb" " nb ns z ps pb" " nb ns z ps pb" "0.5 nb ns z ps pb" " nb ns z ps pb" " nb ns z ps pb" " nb ns z ps pb" " nb ns z ps pb" "0.0 |- - - |- + - - - - - + - - - + -|-- - -|" " -100 -60 0 60 100 (Defaults)"

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Signing-up typically involves downloading a browser plug-in whose function is to enable the user s machine to poll the push-server at preset intervals (usually determined at set-up, by the user) In some cases, the plug-in may inform the push server of which channels ( news , sport , etc) the user has an interest If the polling by the user s machine detects that the server is agging-up a change to a channel, then the plug-in downloads this information and may alert the user to the arrival of new.

Because bonds are priced both in terms of dollar price and yield, an overview of various yield types is appropriate Just as there are nominal yield spreads and forward yield spreads, there are also option-adjusted spreads (OASs) Refer again to the cash flow triangle and the notion of forwards building on spots, and options, in turn, building on forwards Recall that a spot spread is defined as being the difference (in basis points) between two spot yield levels (and being equivalent to a nominal yield spread when the spot curve is a par bond curve) and that a forward spread is the difference (in bps) between two forward yield levels derived from the entire relevant portion of respective spot curves (and where the forward curve is equivalent to a spot curve when the spot curve is flat).

P(b, c) , P(b)P(c)

f12 (xi12 | 1 , 2 )

A nominal spread typically reflects a measure of one security s richness or cheapness relative to another Thus, it can be of interest to investors as a way of comparing one security against another Similarly, a forward spread also can be used by investors to compare two securities, particularly when it would be of interest to incorporate the information contained within a more complete yield curve (as a forward yield in fact does) An OAS can be a helpful valuation tool for investors when a security has optionlike features 4 examines such security types in detail Here the objective is to introduce an OAS and show how it can be of assistance as a valuation tool for fixed income investors If a bond has an option embedded within it, a single security has characteristics of a spot, a forward, and an option all at the same time.

PJM May 7 - 13, 2005

P(A = a, B = b, C = c | A = aobs )

Empirical loss distributions Explicit distributions parameterized using historical data Extreme value theory

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